Long-Term ACE Inhibitor/ARB Use Is Associated with Severe Renal Dysfunction and Acute Kidney Injury in Patients with severe COVID-19: Results from a Referral Center Cohort in the North East of France.
Identifieur interne : 000B85 ( Main/Exploration ); précédent : 000B84; suivant : 000B86Long-Term ACE Inhibitor/ARB Use Is Associated with Severe Renal Dysfunction and Acute Kidney Injury in Patients with severe COVID-19: Results from a Referral Center Cohort in the North East of France.
Auteurs : Abderrahim Oussalah [France] ; Stanislas Gleye [France] ; Isabelle Clerc Urmes [France] ; Elodie Laugel [France] ; Jonas Callet [France] ; Françoise Barbé [France] ; Sophie Orlowski [France] ; Catherine Malaplate [France] ; Isabelle Aimone-Gastin [France] ; Beatrice Maatem Caillierez [France] ; Marc Merten [France] ; Elise Jeannesson [France] ; Raphaël Kormann [France] ; Jean-Luc Olivier [France] ; Rosa-Maria Rodriguez-Guéant [France] ; Farès Namour [France] ; Sybille Bevilacqua [France] ; Marie-Reine Losser [France] ; Bruno Levy [France] ; Antoine Kimmoun [France] ; Sébastien Gibot [France] ; Nathalie Thilly [France] ; Luc Frimat [France] ; Evelyne Schvoerer [France] ; Jean-Louis Guéant [France]Source :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [ 1537-6591 ] ; 2020.
Abstract
BACKGROUND
In patients with severe COVID-19, data are scarce and conflicting regarding whether chronic use of angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) influences disease outcomes. In patients with severe COVID-19, we assessed the association between chronic ACEI/ARB use and the occurrence of kidney, lung, heart, and liver dysfunctions and the severity of the inflammatory reaction as evaluated by biomarkers kinetics, and their association with disease outcomes.
METHODS
We performed a retrospective longitudinal cohort study on consecutive patients with newly diagnosed severe COVID-19. Independent predictors were assessed through receiver operating characteristic analysis, time-series analysis, logistic regression analysis, and multilevel modeling for repeated measures.
RESULTS
On the 149 patients included in the study 30% (44/149) were treated with ACEI/ARB. ACEI/ARB use was independently associated with the following biochemical variations: phosphorus >40 mg/L (odds ratio [OR], 3.35, 95% CI, 1.83-6.14), creatinine >10.1 mg/L (OR, 3.22, 2.28-4.54), and urea nitrogen (UN) >0.52 g/L (OR, 2.65, 1.89-3.73). ACEI/ARB use was independently associated with acute kidney injury, AKI stage ≥1 (OR, 3.28, 2.17-4.94). The daily dose of ACEI/ARB was independently associated with altered kidney markers with an increased risk of +25 to +31% per each 10 mg increment of lisinopril-dose equivalent. In multivariable multilevel modeling, UN >0.52 g/L was independently associated with the risk of acute respiratory failure (OR, 3.54, 1.05-11.96).
CONCLUSIONS
Patients chronically treated with ACEI/ARB who have severe COVID-19 are at increased risk of acute kidney injury. In these patients, the increase in UN associated with ACEI/ARB use could predict the development of acute respiratory failure.
DOI: 10.1093/cid/ciaa677
PubMed: 32623470
PubMed Central: PMC7454376
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type="city">Nancy</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>University of Lorraine, INSERM UMR_S 1256, Nutrition, Genetics, and Environmental Risk Exposure (NGERE), Faculty of Medicine of Nancy, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Lorraine, INSERM UMR_S 1256, Nutrition, Genetics, and Environmental Risk Exposure (NGERE), Faculty of Medicine of Nancy, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Gleye, Stanislas" sort="Gleye, Stanislas" uniqKey="Gleye S" first="Stanislas" last="Gleye">Stanislas Gleye</name><affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy, 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France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Orlowski, Sophie" sort="Orlowski, Sophie" uniqKey="Orlowski S" first="Sophie" last="Orlowski">Sophie Orlowski</name><affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, 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Gastin, Isabelle" sort="Aimone Gastin, Isabelle" uniqKey="Aimone Gastin I" first="Isabelle" last="Aimone-Gastin">Isabelle Aimone-Gastin</name><affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>University of Lorraine, INSERM UMR_S 1256, Nutrition, Genetics, and Environmental Risk Exposure (NGERE), Faculty of Medicine of Nancy, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Lorraine, INSERM UMR_S 1256, Nutrition, Genetics, and Environmental Risk Exposure (NGERE), Faculty of Medicine of Nancy, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Caillierez, Beatrice Maatem" sort="Caillierez, Beatrice Maatem" uniqKey="Caillierez B" first="Beatrice Maatem" last="Caillierez">Beatrice Maatem Caillierez</name><affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Merten, Marc" sort="Merten, Marc" uniqKey="Merten M" first="Marc" last="Merten">Marc Merten</name><affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Jeannesson, Elise" sort="Jeannesson, Elise" uniqKey="Jeannesson E" first="Elise" last="Jeannesson">Elise Jeannesson</name><affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Kormann, Raphael" sort="Kormann, Raphael" uniqKey="Kormann R" first="Raphaël" last="Kormann">Raphaël Kormann</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology, University Hospital of Nancy, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Nephrology, University Hospital of Nancy, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Olivier, Jean Luc" sort="Olivier, Jean Luc" uniqKey="Olivier J" first="Jean-Luc" last="Olivier">Jean-Luc Olivier</name><affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Rodriguez Gueant, Rosa Maria" sort="Rodriguez Gueant, Rosa Maria" uniqKey="Rodriguez Gueant R" first="Rosa-Maria" last="Rodriguez-Guéant">Rosa-Maria Rodriguez-Guéant</name><affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>University of Lorraine, INSERM UMR_S 1256, Nutrition, Genetics, and Environmental Risk Exposure (NGERE), Faculty of Medicine of Nancy, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Lorraine, INSERM UMR_S 1256, Nutrition, Genetics, and Environmental Risk Exposure (NGERE), Faculty of Medicine of Nancy, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Namour, Fares" sort="Namour, Fares" uniqKey="Namour F" first="Farès" last="Namour">Farès Namour</name><affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>University of Lorraine, INSERM UMR_S 1256, Nutrition, Genetics, and Environmental Risk Exposure (NGERE), Faculty of Medicine of Nancy, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Lorraine, INSERM UMR_S 1256, Nutrition, Genetics, and Environmental Risk Exposure (NGERE), Faculty of Medicine of Nancy, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Bevilacqua, Sybille" sort="Bevilacqua, Sybille" uniqKey="Bevilacqua S" first="Sybille" last="Bevilacqua">Sybille Bevilacqua</name><affiliation wicri:level="3"><nlm:affiliation>Department of Infectious Diseases, University Hospital of Nancy, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Infectious Diseases, University Hospital of Nancy, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Losser, Marie Reine" sort="Losser, Marie Reine" uniqKey="Losser M" first="Marie-Reine" last="Losser">Marie-Reine Losser</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anesthesiology and Intensive Care Medicine, University Hospital of Nancy, Vandoeuvre-Lès-Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Anesthesiology and Intensive Care Medicine, University Hospital of Nancy, Vandoeuvre-Lès-Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Levy, Bruno" sort="Levy, Bruno" uniqKey="Levy B" first="Bruno" last="Levy">Bruno Levy</name><affiliation wicri:level="3"><nlm:affiliation>Medical Intensive Care Unit, University Hospital of Nancy, Brabois Hospital, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Medical Intensive Care Unit, University Hospital of Nancy, Brabois Hospital, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Kimmoun, Antoine" sort="Kimmoun, Antoine" uniqKey="Kimmoun A" first="Antoine" last="Kimmoun">Antoine Kimmoun</name><affiliation wicri:level="3"><nlm:affiliation>Medical Intensive Care Unit, University Hospital of Nancy, Brabois Hospital, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Medical Intensive Care Unit, University Hospital of Nancy, Brabois Hospital, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Gibot, Sebastien" sort="Gibot, Sebastien" uniqKey="Gibot S" first="Sébastien" last="Gibot">Sébastien Gibot</name><affiliation wicri:level="3"><nlm:affiliation>Medical Intensive Care Unit, University Hospital of Nancy, Brabois Hospital, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Medical Intensive Care Unit, University Hospital of Nancy, Brabois Hospital, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Thilly, Nathalie" sort="Thilly, Nathalie" uniqKey="Thilly N" first="Nathalie" last="Thilly">Nathalie Thilly</name><affiliation wicri:level="3"><nlm:affiliation>Department of Methodology, Promotion, and Investigation, University Hospital of Nancy, University of Lorraine, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Methodology, Promotion, and Investigation, University Hospital of Nancy, University of Lorraine, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Frimat, Luc" sort="Frimat, Luc" uniqKey="Frimat L" first="Luc" last="Frimat">Luc Frimat</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology, University Hospital of Nancy, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Nephrology, University Hospital of Nancy, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Schvoerer, Evelyne" sort="Schvoerer, Evelyne" uniqKey="Schvoerer E" first="Evelyne" last="Schvoerer">Evelyne Schvoerer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology, University Hospital of Nancy, Nancy, France; Laboratory of Physical Chemistry and Microbiology for the Environment, LCPME UMR 7564 CNRS-UL, Villers-les-Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Virology, University Hospital of Nancy, Nancy, France; Laboratory of Physical Chemistry and Microbiology for the Environment, LCPME UMR 7564 CNRS-UL, Villers-les-Nancy</wicri:regionArea><wicri:noRegion>Villers-les-Nancy</wicri:noRegion><wicri:noRegion>Villers-les-Nancy</wicri:noRegion></affiliation></author><author><name sortKey="Gueant, Jean Louis" sort="Gueant, Jean Louis" uniqKey="Gueant J" first="Jean-Louis" last="Guéant">Jean-Louis Guéant</name><affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>University of Lorraine, INSERM UMR_S 1256, Nutrition, Genetics, and Environmental Risk Exposure (NGERE), Faculty of Medicine of Nancy, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Lorraine, INSERM UMR_S 1256, Nutrition, Genetics, and Environmental Risk Exposure (NGERE), Faculty of Medicine of Nancy, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32623470</idno><idno type="pmid">32623470</idno><idno type="doi">10.1093/cid/ciaa677</idno><idno type="pmc">PMC7454376</idno><idno type="wicri:Area/Main/Corpus">000A90</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000A90</idno><idno type="wicri:Area/Main/Curation">000A90</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000A90</idno><idno type="wicri:Area/Main/Exploration">000A90</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Long-Term ACE Inhibitor/ARB Use Is Associated with Severe Renal Dysfunction and Acute Kidney Injury in Patients with severe COVID-19: Results from a Referral Center Cohort in the North East of France.</title><author><name sortKey="Oussalah, Abderrahim" sort="Oussalah, Abderrahim" uniqKey="Oussalah A" first="Abderrahim" last="Oussalah">Abderrahim Oussalah</name><affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>University of Lorraine, INSERM UMR_S 1256, Nutrition, Genetics, and Environmental Risk Exposure (NGERE), Faculty of Medicine of Nancy, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Lorraine, INSERM UMR_S 1256, Nutrition, Genetics, and Environmental Risk Exposure (NGERE), Faculty of Medicine of Nancy, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Gleye, Stanislas" sort="Gleye, Stanislas" uniqKey="Gleye S" first="Stanislas" last="Gleye">Stanislas Gleye</name><affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Clerc Urmes, Isabelle" sort="Clerc Urmes, Isabelle" uniqKey="Clerc Urmes I" first="Isabelle" last="Clerc Urmes">Isabelle Clerc Urmes</name><affiliation wicri:level="3"><nlm:affiliation>Department of Methodology, Promotion, and Investigation, University Hospital of Nancy, University of Lorraine, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Methodology, Promotion, and Investigation, University Hospital of Nancy, University of Lorraine, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Laugel, Elodie" sort="Laugel, Elodie" uniqKey="Laugel E" first="Elodie" last="Laugel">Elodie Laugel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology, University Hospital of Nancy, Nancy, France; Laboratory of Physical Chemistry and Microbiology for the Environment, LCPME UMR 7564 CNRS-UL, Villers-les-Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Virology, University Hospital of Nancy, Nancy, France; Laboratory of Physical Chemistry and Microbiology for the Environment, LCPME UMR 7564 CNRS-UL, Villers-les-Nancy</wicri:regionArea><wicri:noRegion>Villers-les-Nancy</wicri:noRegion><wicri:noRegion>Villers-les-Nancy</wicri:noRegion></affiliation></author><author><name sortKey="Callet, Jonas" sort="Callet, Jonas" uniqKey="Callet J" first="Jonas" last="Callet">Jonas Callet</name><affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Barbe, Francoise" sort="Barbe, Francoise" uniqKey="Barbe F" first="Françoise" last="Barbé">Françoise Barbé</name><affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Orlowski, Sophie" sort="Orlowski, Sophie" uniqKey="Orlowski S" first="Sophie" last="Orlowski">Sophie Orlowski</name><affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Malaplate, Catherine" sort="Malaplate, Catherine" uniqKey="Malaplate C" first="Catherine" last="Malaplate">Catherine Malaplate</name><affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Aimone Gastin, Isabelle" sort="Aimone Gastin, Isabelle" uniqKey="Aimone Gastin I" first="Isabelle" last="Aimone-Gastin">Isabelle Aimone-Gastin</name><affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>University of Lorraine, INSERM UMR_S 1256, Nutrition, Genetics, and Environmental Risk Exposure (NGERE), Faculty of Medicine of Nancy, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Lorraine, INSERM UMR_S 1256, Nutrition, Genetics, and Environmental Risk Exposure (NGERE), Faculty of Medicine of Nancy, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Caillierez, Beatrice Maatem" sort="Caillierez, Beatrice Maatem" uniqKey="Caillierez B" first="Beatrice Maatem" last="Caillierez">Beatrice Maatem Caillierez</name><affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Merten, Marc" sort="Merten, Marc" uniqKey="Merten M" first="Marc" last="Merten">Marc Merten</name><affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Jeannesson, Elise" sort="Jeannesson, Elise" uniqKey="Jeannesson E" first="Elise" last="Jeannesson">Elise Jeannesson</name><affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Kormann, Raphael" sort="Kormann, Raphael" uniqKey="Kormann R" first="Raphaël" last="Kormann">Raphaël Kormann</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology, University Hospital of Nancy, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Nephrology, University Hospital of Nancy, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Olivier, Jean Luc" sort="Olivier, Jean Luc" uniqKey="Olivier J" first="Jean-Luc" last="Olivier">Jean-Luc Olivier</name><affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Rodriguez Gueant, Rosa Maria" sort="Rodriguez Gueant, Rosa Maria" uniqKey="Rodriguez Gueant R" first="Rosa-Maria" last="Rodriguez-Guéant">Rosa-Maria Rodriguez-Guéant</name><affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>University of Lorraine, INSERM UMR_S 1256, Nutrition, Genetics, and Environmental Risk Exposure (NGERE), Faculty of Medicine of Nancy, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Lorraine, INSERM UMR_S 1256, Nutrition, Genetics, and Environmental Risk Exposure (NGERE), Faculty of Medicine of Nancy, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Namour, Fares" sort="Namour, Fares" uniqKey="Namour F" first="Farès" last="Namour">Farès Namour</name><affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>University of Lorraine, INSERM UMR_S 1256, Nutrition, Genetics, and Environmental Risk Exposure (NGERE), Faculty of Medicine of Nancy, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Lorraine, INSERM UMR_S 1256, Nutrition, Genetics, and Environmental Risk Exposure (NGERE), Faculty of Medicine of Nancy, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Bevilacqua, Sybille" sort="Bevilacqua, Sybille" uniqKey="Bevilacqua S" first="Sybille" last="Bevilacqua">Sybille Bevilacqua</name><affiliation wicri:level="3"><nlm:affiliation>Department of Infectious Diseases, University Hospital of Nancy, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Infectious Diseases, University Hospital of Nancy, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Losser, Marie Reine" sort="Losser, Marie Reine" uniqKey="Losser M" first="Marie-Reine" last="Losser">Marie-Reine Losser</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anesthesiology and Intensive Care Medicine, University Hospital of Nancy, Vandoeuvre-Lès-Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Anesthesiology and Intensive Care Medicine, University Hospital of Nancy, Vandoeuvre-Lès-Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Levy, Bruno" sort="Levy, Bruno" uniqKey="Levy B" first="Bruno" last="Levy">Bruno Levy</name><affiliation wicri:level="3"><nlm:affiliation>Medical Intensive Care Unit, University Hospital of Nancy, Brabois Hospital, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Medical Intensive Care Unit, University Hospital of Nancy, Brabois Hospital, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Kimmoun, Antoine" sort="Kimmoun, Antoine" uniqKey="Kimmoun A" first="Antoine" last="Kimmoun">Antoine Kimmoun</name><affiliation wicri:level="3"><nlm:affiliation>Medical Intensive Care Unit, University Hospital of Nancy, Brabois Hospital, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Medical Intensive Care Unit, University Hospital of Nancy, Brabois Hospital, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Gibot, Sebastien" sort="Gibot, Sebastien" uniqKey="Gibot S" first="Sébastien" last="Gibot">Sébastien Gibot</name><affiliation wicri:level="3"><nlm:affiliation>Medical Intensive Care Unit, University Hospital of Nancy, Brabois Hospital, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Medical Intensive Care Unit, University Hospital of Nancy, Brabois Hospital, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Thilly, Nathalie" sort="Thilly, Nathalie" uniqKey="Thilly N" first="Nathalie" last="Thilly">Nathalie Thilly</name><affiliation wicri:level="3"><nlm:affiliation>Department of Methodology, Promotion, and Investigation, University Hospital of Nancy, University of Lorraine, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Methodology, Promotion, and Investigation, University Hospital of Nancy, University of Lorraine, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Frimat, Luc" sort="Frimat, Luc" uniqKey="Frimat L" first="Luc" last="Frimat">Luc Frimat</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology, University Hospital of Nancy, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Nephrology, University Hospital of Nancy, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Schvoerer, Evelyne" sort="Schvoerer, Evelyne" uniqKey="Schvoerer E" first="Evelyne" last="Schvoerer">Evelyne Schvoerer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology, University Hospital of Nancy, Nancy, France; Laboratory of Physical Chemistry and Microbiology for the Environment, LCPME UMR 7564 CNRS-UL, Villers-les-Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Virology, University Hospital of Nancy, Nancy, France; Laboratory of Physical Chemistry and Microbiology for the Environment, LCPME UMR 7564 CNRS-UL, Villers-les-Nancy</wicri:regionArea><wicri:noRegion>Villers-les-Nancy</wicri:noRegion><wicri:noRegion>Villers-les-Nancy</wicri:noRegion></affiliation></author><author><name sortKey="Gueant, Jean Louis" sort="Gueant, Jean Louis" uniqKey="Gueant J" first="Jean-Louis" last="Guéant">Jean-Louis Guéant</name><affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>University of Lorraine, INSERM UMR_S 1256, Nutrition, Genetics, and Environmental Risk Exposure (NGERE), Faculty of Medicine of Nancy, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Lorraine, INSERM UMR_S 1256, Nutrition, Genetics, and Environmental Risk Exposure (NGERE), Faculty of Medicine of Nancy, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author></analytic><series><title level="j">Clinical infectious diseases : an official publication of the Infectious Diseases Society of America</title><idno type="eISSN">1537-6591</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>In patients with severe COVID-19, data are scarce and conflicting regarding whether chronic use of angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) influences disease outcomes. In patients with severe COVID-19, we assessed the association between chronic ACEI/ARB use and the occurrence of kidney, lung, heart, and liver dysfunctions and the severity of the inflammatory reaction as evaluated by biomarkers kinetics, and their association with disease outcomes.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>We performed a retrospective longitudinal cohort study on consecutive patients with newly diagnosed severe COVID-19. Independent predictors were assessed through receiver operating characteristic analysis, time-series analysis, logistic regression analysis, and multilevel modeling for repeated measures.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>On the 149 patients included in the study 30% (44/149) were treated with ACEI/ARB. ACEI/ARB use was independently associated with the following biochemical variations: phosphorus >40 mg/L (odds ratio [OR], 3.35, 95% CI, 1.83-6.14), creatinine >10.1 mg/L (OR, 3.22, 2.28-4.54), and urea nitrogen (UN) >0.52 g/L (OR, 2.65, 1.89-3.73). ACEI/ARB use was independently associated with acute kidney injury, AKI stage ≥1 (OR, 3.28, 2.17-4.94). The daily dose of ACEI/ARB was independently associated with altered kidney markers with an increased risk of +25 to +31% per each 10 mg increment of lisinopril-dose equivalent. In multivariable multilevel modeling, UN >0.52 g/L was independently associated with the risk of acute respiratory failure (OR, 3.54, 1.05-11.96).</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Patients chronically treated with ACEI/ARB who have severe COVID-19 are at increased risk of acute kidney injury. In these patients, the increase in UN associated with ACEI/ARB use could predict the development of acute respiratory failure.</p></div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32623470</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>01</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1537-6591</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Jul</Month><Day>05</Day></PubDate></JournalIssue><Title>Clinical infectious diseases : an official publication of the Infectious Diseases Society of America</Title><ISOAbbreviation>Clin. Infect. Dis.</ISOAbbreviation></Journal><ArticleTitle>Long-Term ACE Inhibitor/ARB Use Is Associated with Severe Renal Dysfunction and Acute Kidney Injury in Patients with severe COVID-19: Results from a Referral Center Cohort in the North East of France.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">ciaa677</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1093/cid/ciaa677</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">In patients with severe COVID-19, data are scarce and conflicting regarding whether chronic use of angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) influences disease outcomes. In patients with severe COVID-19, we assessed the association between chronic ACEI/ARB use and the occurrence of kidney, lung, heart, and liver dysfunctions and the severity of the inflammatory reaction as evaluated by biomarkers kinetics, and their association with disease outcomes.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We performed a retrospective longitudinal cohort study on consecutive patients with newly diagnosed severe COVID-19. Independent predictors were assessed through receiver operating characteristic analysis, time-series analysis, logistic regression analysis, and multilevel modeling for repeated measures.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">On the 149 patients included in the study 30% (44/149) were treated with ACEI/ARB. ACEI/ARB use was independently associated with the following biochemical variations: phosphorus >40 mg/L (odds ratio [OR], 3.35, 95% CI, 1.83-6.14), creatinine >10.1 mg/L (OR, 3.22, 2.28-4.54), and urea nitrogen (UN) >0.52 g/L (OR, 2.65, 1.89-3.73). ACEI/ARB use was independently associated with acute kidney injury, AKI stage ≥1 (OR, 3.28, 2.17-4.94). The daily dose of ACEI/ARB was independently associated with altered kidney markers with an increased risk of +25 to +31% per each 10 mg increment of lisinopril-dose equivalent. In multivariable multilevel modeling, UN >0.52 g/L was independently associated with the risk of acute respiratory failure (OR, 3.54, 1.05-11.96).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Patients chronically treated with ACEI/ARB who have severe COVID-19 are at increased risk of acute kidney injury. In these patients, the increase in UN associated with ACEI/ARB use could predict the development of acute respiratory failure.</AbstractText><CopyrightInformation>© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Oussalah</LastName><ForeName>Abderrahim</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University of Lorraine, INSERM UMR_S 1256, Nutrition, Genetics, and Environmental Risk Exposure (NGERE), Faculty of Medicine of Nancy, Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gleye</LastName><ForeName>Stanislas</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Clerc Urmes</LastName><ForeName>Isabelle</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Methodology, Promotion, and Investigation, University Hospital of Nancy, University of Lorraine, Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Laugel</LastName><ForeName>Elodie</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Virology, University Hospital of Nancy, Nancy, France; Laboratory of Physical Chemistry and Microbiology for the Environment, LCPME UMR 7564 CNRS-UL, Villers-les-Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Callet</LastName><ForeName>Jonas</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Barbé</LastName><ForeName>Françoise</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Orlowski</LastName><ForeName>Sophie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Malaplate</LastName><ForeName>Catherine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aimone-Gastin</LastName><ForeName>Isabelle</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University of Lorraine, INSERM UMR_S 1256, Nutrition, Genetics, and Environmental Risk Exposure (NGERE), Faculty of Medicine of Nancy, Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Caillierez</LastName><ForeName>Beatrice Maatem</ForeName><Initials>BM</Initials><AffiliationInfo><Affiliation>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Merten</LastName><ForeName>Marc</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jeannesson</LastName><ForeName>Elise</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kormann</LastName><ForeName>Raphaël</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Nephrology, University Hospital of Nancy, Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Olivier</LastName><ForeName>Jean-Luc</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rodriguez-Guéant</LastName><ForeName>Rosa-Maria</ForeName><Initials>RM</Initials><AffiliationInfo><Affiliation>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University of Lorraine, INSERM UMR_S 1256, Nutrition, Genetics, and Environmental Risk Exposure (NGERE), Faculty of Medicine of Nancy, Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Namour</LastName><ForeName>Farès</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University of Lorraine, INSERM UMR_S 1256, Nutrition, Genetics, and Environmental Risk Exposure (NGERE), Faculty of Medicine of Nancy, Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bevilacqua</LastName><ForeName>Sybille</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Infectious Diseases, University Hospital of Nancy, Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Losser</LastName><ForeName>Marie-Reine</ForeName><Initials>MR</Initials><AffiliationInfo><Affiliation>Department of Anesthesiology and Intensive Care Medicine, University Hospital of Nancy, Vandoeuvre-Lès-Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Levy</LastName><ForeName>Bruno</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Medical Intensive Care Unit, University Hospital of Nancy, Brabois Hospital, Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kimmoun</LastName><ForeName>Antoine</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Medical Intensive Care Unit, University Hospital of Nancy, Brabois Hospital, Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gibot</LastName><ForeName>Sébastien</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Medical Intensive Care Unit, University Hospital of Nancy, Brabois Hospital, Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thilly</LastName><ForeName>Nathalie</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Methodology, Promotion, and Investigation, University Hospital of Nancy, University of Lorraine, Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Frimat</LastName><ForeName>Luc</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Nephrology, University Hospital of Nancy, Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schvoerer</LastName><ForeName>Evelyne</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Virology, University Hospital of Nancy, Nancy, France; Laboratory of Physical Chemistry and Microbiology for the Environment, LCPME UMR 7564 CNRS-UL, Villers-les-Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guéant</LastName><ForeName>Jean-Louis</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University of Lorraine, INSERM UMR_S 1256, Nutrition, Genetics, and Environmental Risk Exposure (NGERE), Faculty of Medicine of Nancy, Nancy, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>07</Month><Day>05</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Clin Infect Dis</MedlineTA><NlmUniqueID>9203213</NlmUniqueID><ISSNLinking>1058-4838</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">SARS-CoV-2</Keyword><Keyword MajorTopicYN="N">acute kidney injury</Keyword><Keyword MajorTopicYN="N">angiotensin receptor blocker</Keyword><Keyword MajorTopicYN="N">angiotensin-converting enzyme inhibitor</Keyword><Keyword MajorTopicYN="N">severe COVID-19</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>05</Month><Day>08</Day></PubMedPubDate><PubMedPubDate 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Thilly</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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